Microwave Supported Solvent Free Reaction of EMME in the Synthesis of Pyrazolopyrimidopyrimidines
D. Shah Rina *
Department of Chemistry, M. G. Science Institute, Navrangpura, Ahmedabad 380 009, India
M. Shah Nirmal
Department of Chemistry, M. G. Science Institute, Navrangpura, Ahmedabad 380 009, India
C. Ramani Vivek
Department of Chemistry, M. G. Science Institute, Navrangpura, Ahmedabad 380 009, India
*Author to whom correspondence should be addressed.
Abstract
Diethyl ethoxy-methylenemalonate the versatile reagent used to synthesize pyrazolopyrimidopyrimidines (3) as antimicrobial agents from the reaction between EMME and 1-substituted 3-(methylthio) 3H-pyrazolo [3,4-d]pyrimidine-4-amines (1) using Gould Jacob reaction. A comparison of conventional and microwave supported solvent-free reaction has been studied.
Keywords: EMME, pyrazolopyrimidopyrimidines, Gould-Jacob reaction, microwave heating