Single-step Syznthesis of Coenzyme Q0
Yi-Yu Yan
School of Pharmacy, Jiangsu Key Laboratory for Bioresources of Saline Soils, Yancheng Teachers University, Hope Avenue South Road No. 2, Yancheng, 224007, Jiangsu Province, P. R. China.
Yong-Fu Qiu
School of Pharmacy, Jiangsu Key Laboratory for Bioresources of Saline Soils, Yancheng Teachers University, Hope Avenue South Road No. 2, Yancheng, 224007, Jiangsu Province, P. R. China.
Tian-Li Zhang
School of Pharmacy, Jiangsu Key Laboratory for Bioresources of Saline Soils, Yancheng Teachers University, Hope Avenue South Road No. 2, Yancheng, 224007, Jiangsu Province, P. R. China.
Yu-Bei He
School of Pharmacy, Jiangsu Key Laboratory for Bioresources of Saline Soils, Yancheng Teachers University, Hope Avenue South Road No. 2, Yancheng, 224007, Jiangsu Province, P. R. China.
Shi Qi
School of Pharmacy, Jiangsu Key Laboratory for Bioresources of Saline Soils, Yancheng Teachers University, Hope Avenue South Road No. 2, Yancheng, 224007, Jiangsu Province, P. R. China.
Jian-Hua Tian
School of Pharmacy, Jiangsu Key Laboratory for Bioresources of Saline Soils, Yancheng Teachers University, Hope Avenue South Road No. 2, Yancheng, 224007, Jiangsu Province, P. R. China.
Wan-Yue Luo
School of Pharmacy, Jiangsu Key Laboratory for Bioresources of Saline Soils, Yancheng Teachers University, Hope Avenue South Road No. 2, Yancheng, 224007, Jiangsu Province, P. R. China.
Yan Zhao
School of Pharmacy, Jiangsu Key Laboratory for Bioresources of Saline Soils, Yancheng Teachers University, Hope Avenue South Road No. 2, Yancheng, 224007, Jiangsu Province, P. R. China.
Jin Wang *
School of Pharmacy, Jiangsu Key Laboratory for Bioresources of Saline Soils, Yancheng Teachers University, Hope Avenue South Road No. 2, Yancheng, 224007, Jiangsu Province, P. R. China.
*Author to whom correspondence should be addressed.
Abstract
A new method for the preparation of 2-methyl-5,6-dimethoxy-1,4-benzoquinone (Coenzyme Q0) was developed. This improved process in one step by the oxidation of 3,4,5-trimethoxytoluene to coenzyme Q0 by simple oxidation using potassium or ammonium persulfate under transition -metal free conditions.
Keywords: Coenzyme Q0, 3,4,5-trimethoxytoluene, potassium persulfate.