A Green and Scalable Synthesis of 1-Amino Anthraquinone
Bin Lu
School of Pharmacy, Jiangsu Key Laboratory for Bioresources of Saline Soils, Yancheng Teachers University, Hope Avenue South Road No.2, Yancheng, 224007, Jiangsu Province, P.R. China.
Yi-Yu Yan
School of Pharmacy, Jiangsu Key Laboratory for Bioresources of Saline Soils, Yancheng Teachers University, Hope Avenue South Road No.2, Yancheng, 224007, Jiangsu Province, P.R. China.
Yong-Fu Qiu
School of Pharmacy, Jiangsu Key Laboratory for Bioresources of Saline Soils, Yancheng Teachers University, Hope Avenue South Road No.2, Yancheng, 224007, Jiangsu Province, P.R. China.
Tian-Li Zhang
School of Pharmacy, Jiangsu Key Laboratory for Bioresources of Saline Soils, Yancheng Teachers University, Hope Avenue South Road No.2, Yancheng, 224007, Jiangsu Province, P.R. China.
Shi Qi
School of Pharmacy, Jiangsu Key Laboratory for Bioresources of Saline Soils, Yancheng Teachers University, Hope Avenue South Road No.2, Yancheng, 224007, Jiangsu Province, P.R. China.
Jian-Hua Tian
School of Pharmacy, Jiangsu Key Laboratory for Bioresources of Saline Soils, Yancheng Teachers University, Hope Avenue South Road No.2, Yancheng, 224007, Jiangsu Province, P.R. China.
Wan-Yue Luo
School of Pharmacy, Jiangsu Key Laboratory for Bioresources of Saline Soils, Yancheng Teachers University, Hope Avenue South Road No.2, Yancheng, 224007, Jiangsu Province, P.R. China.
Xiao Hu *
Yancheng Teachers University Library, Hope Avenue South Road No.2, Yancheng, 224007, Jiangsu Province, P.R. China.
Jin Wang *
School of Pharmacy, Jiangsu Key Laboratory for Bioresources of Saline Soils, Yancheng Teachers University, Hope Avenue South Road No.2, Yancheng, 224007, Jiangsu Province, P.R. China.
*Author to whom correspondence should be addressed.
Abstract
1-amino anthraquinone (2) is the most important intermediate in the synthesis of acid dyes. This paper presents a new method for the preparation of title compound (2) in a highly chemo- and regioselective reduction of 1-nitro anthraquinone (1) by NaHS in water under mild conditions. This protocol is clean, operationally simple, easy work-up and could be applied in the industrial production.
Graphical_Abstract
Keywords: Nitroanthraquinone, aminoanthraquinone, reduction