Synthesis, Characterization and Biological Activity of New Amides Containing Azo Moieties
Elham Abdalrahem Bin Selim
Chemistry Department, Faculty of Science, Hadhramout University, Mukalla, Hadhramout, Yemen.
Mohammed Hadi Al–Douh
*
Chemistry Department, Faculty of Science, Hadhramout University, Mukalla, Hadhramout, Yemen.
Samia Mabrook Bin Mahram
Chemistry Department, Faculty of Science, Hadhramout University, Mukalla, Hadhramout, Yemen.
Wedad Mohammed Al–Haik
Department of Biology, Faculty of Science, Hadhramout University, Mukalla, Hadhramout, Yemen.
Khalid Saeed Sonbol
Department of Biology, Faculty of Science, Hadhramout University, Mukalla, Hadhramout, Yemen and Alsalam Medical Specialized Center, Mukalla, Hadhramout, Yemen.
*Author to whom correspondence should be addressed.
Abstract
Three new amide compounds 6, 8 and 9 were derived from diazo dye 4. 4-Hydroxy-3-methoxy-5-(2,6-dinitrophenyl) benzaldehyde 4 was reacted separately with compounds 5 and 7 to obtain 6 and 8, respectively. The amide compound 9 was synthesized by two different methods. The reaction between 6 and a diacyl chloride compound 7 gave compound 9. Also, compound 9 was produced via the reaction of compound 8 and an N-terminus compound 5. All compounds were characterized by their melting points, UV-Vis, and FTIR spectra. Moreover, the mass spectrum and elemental analysis of compound 9 were determined. All three synthesized compounds were tested against P. mirabilis, E. coli, and S. aureus at different concentrations and showed significant results.
Keywords: Synthesis, amide, vanillin, azo functional group, UV–Vis, FTIR, MS