Synthesis; Characterization and Anti-inflammatory Activity of N'-{4-[2-(1H-benzimidazol-2-YL)-2-oxoethyl] phenyl}-2-hydroxyacetohydrazide and it’s Derivatives
Rohit Jaysing Bhor *
Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy Pravaranagar, Tal-Rahata, District-Ahmednagar, Maharashtra, India.
Komal Sakharam Sable
Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy Pravaranagar, Tal-Rahata, District-Ahmednagar, Maharashtra, India.
*Author to whom correspondence should be addressed.
Abstract
A fundamental structural feature of benzimidazoles, a group of heterocyclic, aromatic compounds, is the fusion of a six-membered benzene ring with a five-membered imidazole moiety. Formic acid, Acetyl chloride, hydrazine hydrate, Benzene-1,2-diol, Glycolic Acid, Benzoyl chloride, Methyl chloride, Ethyl chloride, Benzamide, and other chemicals were utilized in this research study. In this research study different methods were used such as TLC, IR spectra, 1H-NMR, and MS. These derivatives were tested for their anti-inflammatory activity determined by rat-paw- oedema method. It was determined that the synthetic chemicals ranged from BA to BK. When compared to common medicines like Indomethacin, the compounds Benzimidazole (BA), 1-(1H-benzimidazole-2-yl)-(3-hydrazinylphenyl) ethanone (BC), N’- {4- [2 - (1H-benzimidazol-2yl) -2- oxoethyl] phenyl} -2-hydroxyaceto hydrazide N- (3-nitrophenyl) acetamide (BK), N’- {4- [2 - (1H-benzimidazol-2yl) -2- oxoethyl] phenyl} -2-hydroxyaceto hydrazide N- (2-nitrophenyl) acetamide (BJ),N’- {4- [2- (1H–benzimidazol-2-yl) -2 -oxoethyl] phenyl} -2-hydroxyaceto hydrazide –N - phenylacetamide (BI) were found to be the most potent.
Keywords: Benzimidazole, hydroxy acetic acid, benzene-1, 2-diol, 2- nitro aniline, indometacin, anti-inflammatory activity